Chris Wai Hang Lo

BPharm (HKU), RPh (HK)

Hi there! I am Chris Lo! I am a researcher working in statistical genetics and precision medicine. I am also a registered pharmacist by training, based in Hong Kong.

Since 2022, I joined the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London. My work is primarily related to the Antidepressant Medications: Biology, Exposure & Response (AMBER) Study, to study the genetics of antidepressant response using electronic health records and clinical trials.

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Research Interests and Current Work

My research interests revolve around pharmacogenomics, to study how genetics affect an individual responds or getting adverse events from medications.

I am also interested in large-scale pharmacoepidemiological studies to ensure safe and appropriate use of pharmacotherapy.

These large datasets include biobanks with linked electronic health records in the UK, such as UK Biobank, Genes and Health and GLAD.

I am also involved in the Psychiatric Genomics Consortium, as part of the Treatment Response working group of the PGC. I am responsible for managing clinical trial data for the working group.




About Me

I grew up Hong Kong and graduated from the University of Hong Kong in 2021 as Bachelor in Pharmacy.

Afterwards, I received clinical training in local hospitals, and officially registered as a pharmacist in 2022.

In autumn 2022, I moved to the UK do a PhD in Statistical genetics in the Statistical Genetics Unit, at the Social, Genetic and Developmental Psychiatry Centre at King’s.

You can find me on Twitter here as @chrislowh and LinkedIn profile here.



Publications

2025

Lo CWH, Gillett AC, Iveson MH, et al., Lewis CM. Antidepressant switching as a proxy phenotype for drug non-response: investigating clinical, demographic and genetic characteristics. Biological Psychiatry Global Open Science. 2025 Apr 10:100502.

Kamp M, Lo CWH, et al., Lewis CM, AMBER Research Team. Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank. Psychological Medicine. 2025 Jan;55:e80.

2024

Li D, Pain O, Fabbri C, Wong WL, Lo CWH, et al. Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis. Translational psychiatry. 2024 Jul 19;14(1):296.

2023

Lo CWH, Pathadka S, Qin SX, et al., Chan EW. Neuropsychiatric events associated with montelukast in patients with asthma: a systematic review. European Respiratory Review. 2023 Sep 27;32(169).

2021

Tsoi MF, Lo CWH, Cheung TT, Cheung BM. Blood lead level and risk of hypertension in the United States National Health and Nutrition Examination Survey 1999–2016. Scientific reports. 2021 Feb 4;11(1):3010.

Lo CWH, Fei Y, Cheung BM. Cardiovascular outcomes in trials of new antidiabetic drug classes. Cardiac Failure Review. 2021 Mar 5;7:e04.


Any questions?

Please post questions as an issue on the T-Rx GitHub repo here.

The T-Rx package is currently under beta testing. Most functions should have adequate documentation on possible errors.

Please kindly reach out to Chris Lo () for feedback on documentation.